When Susan Murphy (Reese Witherspoon) is unexpectedly clobbered by a meteor full of outer space gunk, she mysteriously grows to 49-feet-11-inches tall and is instantly labeled a ?Monster? named Ginormica. The military jumps into action, and she is captured by General W.R. Monger (Kiefer Sutherland) and held in a secret government compound filled with other ?monsters? like herself. This ragtag group consists of the brilliant but insect-headed Dr. Cockroach P.H.D. (Hugh Laurie); the macho half-ape-half-fish The Missing Link (Will Arnett); the gelatinous and indestructible B.O.B. (Seth Rogen); and the 350-foot grub called Insectosaurus. Their confinement time is cut short however, when a mysterious alien robot lands on Earth and the motley crew of Monsters is called into action to save the world from imminent destruction.
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